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31

May 2026

Is Collagen Generally Recognized as Safe (GRAS) in the United States?
Is Collagen Generally Recognized as Safe (GRAS) in the United States?
By
Collagen continues to dominate the functional ingredient market across foods, beverages, supplements, and beauty-from-within products. From protein powders and ready-to-drink beverages to gummies and nutrition bars, collagen ingredients are now […] Read More >>

29

May 2026

GRAS for GLP-1 Inspired Supplements: Regulatory Strategy & Ingredient Considerations
GRAS for GLP-1 Inspired Supplements: Regulatory Strategy & Ingredient Considerations
By
As GLP-1 receptor agonist drugs like Ozempic®, Wegovy®, and Mounjaro® continue to dominate conversations around weight management and metabolic health, supplement companies are increasingly exploring ingredients that may support the […] Read More >>

29

May 2026

What GRAS Means For Pet Foods in the United States
What GRAS Means For Pet Foods in the United States
By
Pet food innovation is moving quickly across the United States. From novel proteins and functional ingredients to fermentation-derived compounds and upcycled materials, manufacturers are continuing to develop increasingly sophisticated products […] Read More >>

29

Apr 2026

GRAS vs NDI: What Ingredient Manufacturers Need to Know
GRAS vs NDI: What Ingredient Manufacturers Need to Know
By
Why this distinction matters more than ever For companies developing ingredients for the U.S. market, one question comes up early—and often: Should this ingredient go the GRAS route, or require […] Read More >>

24

Apr 2026

Dietary Supplement cGMPs 2026: FDA Enforcement Is Rising — and Most Companies Are Not Ready
Dietary Supplement cGMPs 2026: FDA Enforcement Is Rising — and Most Companies Are Not Ready
By
Register for Dietary Supplement cGMP Online Training | 21 CFR Part 111 There have been no major structural changes to 21 CFR Part 111 in recent years. However, focusing on […] Read More >>

23

Apr 2026

State-Level GRAS Disclosure Bills: What They Mean for Food Manufacturers
State-Level GRAS Disclosure Bills: What They Mean for Food Manufacturers
By
State-level scrutiny of Generally Recognized as Safe (GRAS) substances is no longer limited to New York. While New York’s Food Safety and Chemical Disclosure Act has drawn significant attention because […] Read More >>

21

Apr 2026

FDA Reverses Position on NMN: A New Pathway for Dietary Supplments
FDA Reverses Position on NMN: A New Pathway for Dietary Supplments
By
The U.S. Food and Drug Administration (FDA) has officially reversed its position on beta-nicotinamide mononucleotide (NMN), concluding that the ingredient is not excluded from the definition of a dietary supplement. […] Read More >>

31

Mar 2026

What are cGMPs and Why Do They Matter for Dietary Supplements?
What are cGMPs and Why Do They Matter for Dietary Supplements?
By
Register Now for Dietary Supplement cGMP Online Training | 21 CFR Part 111 In the U.S. dietary supplement industry, product quality is not something that can be assumed. It must […] Read More >>

22

Aug 2025

FDA Color Additive Petition: What Red 3 Bans Mean for Ingredient Companies
FDA Color Additive Petition: What Red 3 Bans Mean for Ingredient Companies
By
Background On January 15, 2025, the FDA revoked authorization for FD&C Red No. 3 (erythrosine) for use in foods, including dietary supplements, and in ingested drugs. The agency followed a […] Read More >>

06

Jun 2025

FDA’s AI Rollout: What Elsa and CDRH-GPT Mean for Regulatory Submissions in the U.S.
FDA’s AI Rollout: What Elsa and CDRH-GPT Mean for Regulatory Submissions in the U.S.
By
On June 2, 2025, the U.S. Food and Drug Administration (FDA) officially launched Elsa, a generative AI tool designed to assist FDA staff with core functions such as reviewing clinical […] Read More >>

15

Mar 2023

FDA Launches New Ingredient Directory for Dietary Supplements
FDA Launches New Ingredient Directory for Dietary Supplements
By
On March 6, 2023, the Food and Drug Administration (FDA) launched a new directory of ingredients used in dietary supplements. The directory will be a “one-stop shop” for ingredient information […] Read More >>

29

Dec 2022

FTC Issues Dietary Supplement Claims Guidance for First Time since 1998
FTC Issues Dietary Supplement Claims Guidance for First Time since 1998
By
On December 20, 2022, the Federal Trade Commission (FTC) published “Health Products Compliance Guidance” for advertising and marketing health claims. The guidance document replaces “Dietary Supplements: An Advertising Guide for […] Read More >>

23

Nov 2022

FDA Issues Warning Letters to Seven Dietary Supplement Manufacturers for Using Drug Claims
FDA Issues Warning Letters to Seven Dietary Supplement Manufacturers for Using Drug Claims
By
On Thursday, November 17, 2022, the Center for Food Safety and Applied Nutrition issued seven warning letters to manufacturers of supplements marketed for the promotion of cardiovascular health. The dietary […] Read More >>

14

Nov 2022

FDA Concludes that Nicotinamide Mononucleotide (NMN) Cannot be Marketed or Sold in Dietary Supplements
FDA Concludes that Nicotinamide Mononucleotide (NMN) Cannot be Marketed or Sold in Dietary Supplements
By
The FDA recently published responses to several new dietary ingredient notifications (NDIN) submitted for nicotinamide mononucleotide (most notably the November 8, 2022 response to Inner Mongolia Kingdomway Pharmaceutical Ltd. “Kingdomway”). […] Read More >>

25

Oct 2022

GRAS, New Dietary Ingredients (NDI’s), Old Dietary Ingredients (ODI’s), and Food Additives – Is Your Product Classified Correctly?
GRAS, New Dietary Ingredients (NDI’s), Old Dietary Ingredients (ODI’s), and Food Additives – Is Your Product Classified Correctly?
By
To be used in foods and dietary supplements, ingredients must: be determined to be Generally Recognized as Safe (GRAS), be approved as a New Dietary Ingredient (NDI), be considered an […] Read More >>

15

Apr 2021

Amazon Updates Requirements For Dietary Supplements
Amazon Updates Requirements For Dietary Supplements
By
Just months after announcing that new documentation would be required for supplements sold on their marketplace, Amazon has again updated their requirements, this time without an announcement. In this latest […] Read More >>

14

Apr 2021

Safe Quality Food Certification Program and Dietary Supplements
Safe Quality Food Certification Program and Dietary Supplements
By
Are you concerned that the dietary products that you consume are safe and that the environment in which they are manufactured is up to a particular standard? Well, you should […] Read More >>

18

Dec 2020

Stricter Documentation Now Required for Supplements Sold on Amazon
Stricter Documentation Now Required for Supplements Sold on Amazon
By
Dietary supplement marketers selling on Amazon are now being asked to provide testing results and other manufacturing information on their supplement products in order to remain on Amazon’s site for […] Read More >>

22

Feb 2019

Changes in the Dietary Supplement Environment: Is your Product Compliant?
Changes in the Dietary Supplement Environment: Is your Product Compliant?
By
On February 11, 2019, FDA Commissioner Dr. Scott Gottlieb announced that the regulatory framework for dietary supplements is expected to change. It has been determined that changes are necessary due […] Read More >>

05

Jul 2018

OEHHA Clarifies Prop 65 Cancer Warning Requirement for Coffee
OEHHA Clarifies Prop 65 Cancer Warning Requirement for Coffee
By
Prop 65, California’s right-to-know law that requires a clear and reasonable warning for chemicals known to cause cancer or reproductive harm, finds that coffee does not require a cancer warning. […] Read More >>

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