- FDA-Notified GRAS – where you petition the FDA to review your ingredient and provide a GRAS status by way of a “No Questions/Objections Letter”
- Self-Affirmed GRAS – where you self-affirm that your product is Generally Recognized As Safe based on the conclusion of a scientific expert panel
In either case, the applicant must demonstrate that the substance will not cause harm under the conditions of its intended use. This includes the provision of scientific evidence supporting the safety of the substance.